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Its upstream network involves multiple immune receptors (e.g., TLRs, IFNAR), adaptors (MYD88), ubiquitin ligases (A20), and transcriptional regulators such as NF-κB, IRFs, STATs, C/EBPβ, and PKC, forming a multilayered signaling system that finely tunes ACOD1 transcriptional activity

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2.3 GSH and the γ-glutamyl cycle Alton Meister first described the γ-glutamyl cycle in the early 1970’s, which allows GSH to serve as a continuous source of cysteine [19] (Figure 3)